According to the 1896 Sanborn Fire Insurance Map, four wooden commercial structures occupied the site (a millinery, harness, grocery, and barbershop). These buildings were destroyed by the 1900 Pomeroy fire. Dr. and C.E. Kuykendall began construction on their new brick block immediately after the fire. The building was the second brick structure to be completed after the fire. J.N. Cardwell moved his general store into the west storefront and stayed until circa 1909 when he moved to a different location. and the Taylor shoe store moved into Cardwell's storefront.

Other uses for the western storefront included a clothing store and the Central Market. Loy and Stevenson Confectionery shop were the first to occupy the eastern storefront. The partners maintained their business until 1906 when George Simenstad established a jewelry store in the building. About 1963, the Pomeroy Pharmacy moved from their long-time location at 782 Main Street to the Kuykendall Block.

According to Ray Cardwell [Ray Cardwell: Cardwell's, 2010], during the early 1970's, Mona Wolf had "Wolf's Fabrics" in the back of the pharmacy. The pharmacy later merged with Brown's Drug Store and took over both storefronts and still occupies the building.

The one-story painted brick building has a cornice decorated with an offset peaked parapet, corbeled dripcourses, raised rusticated pilasters accented with corbels and topped with pyramidal caps, transom window openings covered with wood panels, and a recessed entrance on the west bay. The original entrance on the west bay has been changed to a window.

Description and much of the Cultural Data based on
research by Donovan & Associates